{"id":30435,"date":"2020-02-26T12:13:16","date_gmt":"2020-02-26T17:13:16","guid":{"rendered":"https:\/\/blogarchive.utc.edu\/news\/?p=30435"},"modified":"2020-02-28T10:40:06","modified_gmt":"2020-02-28T15:40:06","slug":"fighting-leukemia-at-the-cellular-level","status":"publish","type":"post","link":"https:\/\/blogarchive.utc.edu\/news\/2020\/02\/fighting-leukemia-at-the-cellular-level\/","title":{"rendered":"Fighting leukemia at the cellular level"},"content":{"rendered":"<div id=\"attachment_30438\" class=\"wp-caption aligncenter\" ><img loading=\"lazy\" decoding=\"async\" width=\"1050\" height=\"737\" data-attachment-id=\"30438\" data-permalink=\"https:\/\/blogarchive.utc.edu\/news\/2020\/02\/fighting-leukemia-at-the-cellular-level\/danquah\/\" data-orig-file=\"https:\/\/blogarchive.utc.edu\/news\/files\/2020\/02\/danquah.jpg\" data-orig-size=\"1050,737\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;1&quot;}\" data-image-title=\"danquah\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/blogarchive.utc.edu\/news\/files\/2020\/02\/danquah-1024x719.jpg\" class=\"wp-image-30438\" src=\"https:\/\/blogarchive.utc.edu\/news\/files\/2020\/02\/danquah.jpg\" alt=\"\" style=\"max-width: 100%;\"style=\"max-width: 100%;\" srcset=\"https:\/\/blogarchive.utc.edu\/news\/files\/2020\/02\/danquah.jpg 1050w, https:\/\/blogarchive.utc.edu\/news\/files\/2020\/02\/danquah-300x211.jpg 300w, https:\/\/blogarchive.utc.edu\/news\/files\/2020\/02\/danquah-1024x719.jpg 1024w, https:\/\/blogarchive.utc.edu\/news\/files\/2020\/02\/danquah-768x539.jpg 768w, https:\/\/blogarchive.utc.edu\/news\/files\/2020\/02\/danquah-580x407.jpg 580w, https:\/\/blogarchive.utc.edu\/news\/files\/2020\/02\/danquah-610x428.jpg 610w, https:\/\/blogarchive.utc.edu\/news\/files\/2020\/02\/danquah-250x175.jpg 250w, https:\/\/blogarchive.utc.edu\/news\/files\/2020\/02\/danquah-570x400.jpg 570w\" sizes=\"auto, (max-width: 1050px) 100vw, 1050px\" \/><p class=\"wp-caption-text\">Michael Danquah is a chemical engineering professor and associate dean of the College of Engineering and Computer Science.<\/p><\/div>\n<p>Maximum effectiveness, minimal side effects, least-possible damage to healthy tissue. Scientists have long pursued cancer treatment offering one or more of these benefits, and a researcher at the University of Tennessee at Chattanooga is now among them.<\/p>\n<p>Michael Danquah is researching a highly precise form of treatment delivery\u2014at the nanoscale, molecular level\u2014to fight leukemia.<\/p>\n<p>Danquah researched vaccine production as a chemical engineering doctoral student and today is director of the chemical engineering program at UTC. He is working with pediatric oncologist Dr. Manoo Bhakta of Erlanger Health System to lead a team of researchers funded by the inaugural $25,000 award of the Collaborative Research Grant initiative, a partnership between UTC, the UT College of Medicine and Erlanger.<\/p>\n<h4>Receptors<\/h4>\n<p>They are investigating the use of aptamers\u2014small RNA or DNA molecules that can bind to cellular targets and sometimes called the chemical equivalent of antibodies. Aptamers target \u201creceptors\u201d on the surface of cancer cells. In acute lymphoblastic leukemia (ALL) the type responsible for about 20 percent of all cancer in children and people younger than 20, a unique receptor is found, and Danquah is working on an aptamer to uniquely target that receptor.<\/p>\n<p>\u201cCD19 is a unique receptor, or biomarker, for B-cell acute lymphoblastic leukemia,\u201d Danquah says. \u201cSo, after identifying such a unique receptor, the next stage is: Can you molecularly engineer a DNA aptamer? Can you design a DNA aptamer that can specifically target the CD19 on the tumor? It&#8217;s all about understanding the features of the target receptor and how to develop or design that aptamer to recognize it.\u201d<\/p>\n<p>A successful aptamer design, in which the molecule binds to the targeted receptor, results in something called a \u201cligand,\u201d a general term for a molecule that binds specifically to another molecule. \u201cWhen you have a ligand that can target that specific receptor on the tumor, that&#8217;ll be a significant breakthrough because you\u2019ll have something that can actually identify a particular receptor on the tumor,\u201d Danquah says.<\/p>\n<p>Since receiving the $25,000 funding at the end of 2018. Danquah says great progress has already been made. The work has yielded two aptamer designs\u2014one a DNA molecule, the other an RNA molecule\u2014that can target the CD19 receptor. \u201cThe next stage is to synthesize these two aptamers and then test the binding mechanism,\u201d Danquah says. \u201cOnce that is done, we can incorporate the aptamer into drugs in a process called \u2018molecular coupling\u2019 or \u2018conjugation.\u2019 You couple the aptamers onto the drug so that the drug is delivered, the aptamer will navigate the drug to the receptor site.\u201d<\/p>\n<h4>Collaborating Investigators<\/h4>\n<p>\u201cThe collaboration with Erlanger is fantastic,\u201d Danquah says, \u201cand using the UTC SimCenter we&#8217;ve managed to develop the initial models of the aptamer for CD19 that we will study. When we reach the phase of (laboratory studies) and then move to clinical phases, our collaboration with Erlanger will make that happen much more easily because clinical research is what they do.\u201d<\/p>\n<p>In anticipation of the years of work ahead for this project, Danquah will be working with two doctoral students with a similar research focus. \u201cBoth students started this fall, and once they&#8217;re done with their courses, they will be actively involved, and I&#8217;m excited about that,\u201d Danquah says. \u201cThe long-term strategy that I have for this project is to be able to build some form of Biomedical Center of Excellence that will be looking into developing new diagnostics and targeted treatment strategies for cancer and advanced pathogen detection systems. When I came to interview to join UTC last year, one of the things that excited me to come here was the opportunity to work with Erlanger.\u201d<\/p>\n<p>Recently, Danquah began collaborating with UTC\u2019s Henry Spratt, a professor and microbiologist, and David Levine, a professor of physical therapy. Spratt and Levine are researching the presence of pathogens in healthcare treatment environments. These microscopic bacteria live on surfaces or may be airborne and cause infection in people exposed to them. With Danquah, Spratt and Levine are examining the possibility of incorporating aptamers in detection of those pathogens.<\/p>\n<p>Meanwhile, Danquah is staying busy looking for funding sources for his research. He has a list of cancer research and prevention funders, including the National Science Foundation, National Institutes of Health and Prevent Cancer Foundation, that he plans to pursue aggressively to support his research. \u201cSince I came here, I&#8217;ve been excited about the possibility of building the biomedical research capabilities of UTC so that we can become like a hub, whereby these hospitals and health-care facilities around us can be collaborators and research partners with us to develop emerging biomedical technologies,\u201d Danquah says. \u201cThat\u2019s my long-term strategy.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Maximum effectiveness, minimal side effects, least-possible damage to healthy tissue. Scientists have long pursued cancer treatment offering one or more of these benefits, and a researcher at the University of Tennessee at Chattanooga is now among them. Michael Danquah is researching a highly precise form of treatment delivery\u2014at the nanoscale, molecular level\u2014to fight leukemia. Danquah&hellip; <\/p>\n<p class=\"more-link-wrap\"><span><a class=\"more-link button text\" href=\"https:\/\/blogarchive.utc.edu\/news\/2020\/02\/fighting-leukemia-at-the-cellular-level\/\"><span>Continue Reading <\/span><\/a><\/span><\/p>\n","protected":false},"author":1300,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","_ef_editorial_meta_date_first-draft-date":"","_ef_editorial_meta_paragraph_assignment":"","_ef_editorial_meta_checkbox_needs-photo":"","_ef_editorial_meta_number_word-count":"","_ef_editorial_meta_checkbox_slider":"","_ef_editorial_meta_checkbox_featurette":"","_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[61,3,7712,64,48007],"tags":[48451,48452,95899,95898],"class_list":{"0":"post-30435","1":"post","2":"type-post","3":"status-publish","4":"format-standard","6":"category-college-of-arts-sciences","7":"category-community","8":"category-faculty-and-staff","9":"category-news","10":"category-research-academics","11":"tag-david-levine","12":"tag-henry-spratt","13":"tag-leukemia","14":"tag-michael-danquah","15":"entry","16":"has-post-thumbnail"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Fighting leukemia at the cellular level | UTC News Archive: Jul 2007 - Oct 2025<\/title>\n<meta name=\"description\" content=\"Maximum effectiveness, minimal side effects, least-possible damage to healthy tissue. Scientists have long pursued cancer treatment offering one or more\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Fighting leukemia at the cellular level | UTC News Archive: Jul 2007 - Oct 2025\" \/>\n<meta property=\"og:description\" content=\"Maximum effectiveness, minimal side effects, least-possible damage to healthy tissue. Scientists have long pursued cancer treatment offering one or more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogarchive.utc.edu\/news\/2020\/02\/fighting-leukemia-at-the-cellular-level\/\" \/>\n<meta property=\"og:site_name\" content=\"UTC News Archive: Jul 2007 - Oct 2025\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/UTChattanooga\" \/>\n<meta property=\"article:published_time\" content=\"2020-02-26T17:13:16+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-02-28T15:40:06+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/blogarchive.utc.edu\/news\/files\/2020\/02\/danquah.jpg\" \/>\n<meta name=\"author\" content=\"Gina Stafford\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@UTChattanooga\" \/>\n<meta name=\"twitter:site\" content=\"@UTChattanooga\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Gina Stafford\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogarchive.utc.edu\\\/news\\\/2020\\\/02\\\/fighting-leukemia-at-the-cellular-level\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogarchive.utc.edu\\\/news\\\/2020\\\/02\\\/fighting-leukemia-at-the-cellular-level\\\/\"},\"author\":{\"name\":\"Gina Stafford\",\"@id\":\"https:\\\/\\\/blogarchive.utc.edu\\\/news\\\/#\\\/schema\\\/person\\\/2fc284569df117e557f2a3a952514f76\"},\"headline\":\"Fighting leukemia at the cellular level\",\"datePublished\":\"2020-02-26T17:13:16+00:00\",\"dateModified\":\"2020-02-28T15:40:06+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogarchive.utc.edu\\\/news\\\/2020\\\/02\\\/fighting-leukemia-at-the-cellular-level\\\/\"},\"wordCount\":807,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/blogarchive.utc.edu\\\/news\\\/2020\\\/02\\\/fighting-leukemia-at-the-cellular-level\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/blogarchive.utc.edu\\\/news\\\/files\\\/2020\\\/02\\\/danquah.jpg\",\"keywords\":[\"David Levine\",\"Henry Spratt\",\"leukemia\",\"michael danquah\"],\"articleSection\":[\"College of Arts and Sciences\",\"Community\",\"Faculty and Staff\",\"News\",\"Research\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogarchive.utc.edu\\\/news\\\/2020\\\/02\\\/fighting-leukemia-at-the-cellular-level\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogarchive.utc.edu\\\/news\\\/2020\\\/02\\\/fighting-leukemia-at-the-cellular-level\\\/\",\"url\":\"https:\\\/\\\/blogarchive.utc.edu\\\/news\\\/2020\\\/02\\\/fighting-leukemia-at-the-cellular-level\\\/\",\"name\":\"Fighting leukemia at the cellular level | UTC News Archive: Jul 2007 - Oct 2025\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogarchive.utc.edu\\\/news\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/blogarchive.utc.edu\\\/news\\\/2020\\\/02\\\/fighting-leukemia-at-the-cellular-level\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/blogarchive.utc.edu\\\/news\\\/2020\\\/02\\\/fighting-leukemia-at-the-cellular-level\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/blogarchive.utc.edu\\\/news\\\/files\\\/2020\\\/02\\\/danquah.jpg\",\"datePublished\":\"2020-02-26T17:13:16+00:00\",\"dateModified\":\"2020-02-28T15:40:06+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/blogarchive.utc.edu\\\/news\\\/#\\\/schema\\\/person\\\/2fc284569df117e557f2a3a952514f76\"},\"description\":\"Maximum effectiveness, minimal side effects, least-possible damage to healthy tissue. 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