{"id":46660,"date":"2022-11-17T08:26:06","date_gmt":"2022-11-17T13:26:06","guid":{"rendered":"https:\/\/blogarchive.utc.edu\/news\/?p=46660"},"modified":"2023-11-04T10:33:33","modified_gmt":"2023-11-04T14:33:33","slug":"if-at-first-you-succeed-utc-chemistry-professor-lands-research-grant-on-initial-attempt","status":"publish","type":"post","link":"https:\/\/blogarchive.utc.edu\/news\/2022\/11\/if-at-first-you-succeed-utc-chemistry-professor-lands-research-grant-on-initial-attempt\/","title":{"rendered":"If at first you succeed: UTC chemistry professor lands research grant on initial attempt"},"content":{"rendered":"
\"Dr.

Dr. Ben Stein works with student Zayda Dominick in Grote Hall. Photo by Angela Foster.<\/p><\/div>\n

Dr. Ben Stein, an assistant professor of chemistry at the University of Tennessee of Chattanooga, has been on the faculty for a little more than a year.<\/p>\n

It\u2019s the first faculty position he\u2019s held in higher education.<\/p>\n

In February, he filed a grant proposal for more than $322,000 from the National Institutes of Health. It\u2019s the first time he\u2019s applied for a grant of any kind.<\/p>\n

In August, he learned he got it. His first reaction?<\/p>\n

\u201cDisbelief,\u201d he said. \u201cIt was a surprise. It was very exciting.\u201d<\/p>\n

Stein was awarded a $322,375 grant from the NIH for a project titled, \u201cCharacterization of non-canonical regulatory pathways in the Caulobacter NtrYX signaling system.\u201d The NIH Research Enhancement Award, known as an R15, is only the second received by a UTC faculty member in recent years.<\/p>\n

Stein, who received a bachelor\u2019s degree from Brown University in 2010 and a Ph.D. from the Massachusetts Institute of Technology in 2016, will be researching how bacterium adapt to changing environments. Knowing how the process works may eventually help in the prevention or treatment of diseases in both humans and animals, he said.<\/p>\n

Understanding the process also may help in agriculture since bacteria are both positive and negative components in plant growth.<\/p>\n

\"Dr.

Dr. Ben Stein<\/p><\/div>\n

Stein said that the three-year NIH grant pays for six undergraduate students to work in the lab-based study, which is a mixture of biochemistry and microbiology.<\/p>\n

\u201cIt\u2019s a large sum for undergraduate-focused lab research,\u201d he said. \u201cFor a university that has six graduate students to support, this might not be as huge, but for us, it\u2019s absolutely big.\u201d<\/p>\n

The study builds on scientific evidence that, whether they\u2019re in humans, animals or soil, disease-causing bacteria can alter themselves to adapt and thrive inside their hosts.<\/p>\n

\u201cIt\u2019s kind of analogous to us. We get burned on the stove; we send signals to our brain; we move our hand away,\u201d Stein said. \u201cIf something infects us, the environment changes for that organism and it needs to adapt.\u201d<\/p>\n

He explained that proteins on the outer edge of each bacteria regularly talk to proteins on the inside through chemical signals. As the environment around the bacteria changes, the outside proteins alert those inside. In turn, those proteins send signals that eventually lead to the bacteria\u2019s DNA\u2014telling it to change to deal with the new environment.<\/p>\n

Much of that process is understood, Stein said, but there\u2019s still a lot to be learned.<\/p>\n

\u201cThese systems have been studied for decades, and there\u2019s a lot known about them. A lot of great scientists have worked on them,\u201d he said. \u201cBut what I think we\u2019ve come to realize over the past decades of research is that we have this very simple model, but it\u2019s very rarely that simple in any one system.\u201d<\/p>\n

Studying bacteria is very familiar to Stein, a native of Ithaca, New York. As a doctoral student at MIT, he focused on proteins that help target obsolete proteins for destruction.<\/p>\n

After earning his Ph.D., he worked in postdoctoral research at Michigan State University and the University of Chicago. His work on bacterium there was a stepping stone to pursuing faculty positions.<\/p>\n

Stein applied for the job at UTC for a couple of reasons.<\/p>\n

\u201cI wanted to work with a mix of students,\u201d he said, “and I liked the urban environment of UTC as well.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"

Assistant Professor of Chemistry Ben Stein was awarded a $322,375 grant from the NIH for the project entitled, \u201cCharacterization of non-canonical regulatory pathways in the Caulobacter NtrYX signaling system.\u201d The NIH Research Enhancement Award, known as an R15, is only the second received by a UTC faculty member in recent years.<\/p>\n

Continue Reading <\/a><\/span><\/p>\n","protected":false},"author":1105,"featured_media":46664,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","_ef_editorial_meta_date_first-draft-date":"","_ef_editorial_meta_paragraph_assignment":"","_ef_editorial_meta_checkbox_needs-photo":"","_ef_editorial_meta_number_word-count":"","_ef_editorial_meta_checkbox_slider":"","_ef_editorial_meta_checkbox_featurette":"","_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[48128,61,7712,8244,64,48007],"tags":[122229,122230,123591],"class_list":{"0":"post-46660","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-chemistry-physics","8":"category-college-of-arts-sciences","9":"category-faculty-and-staff","10":"category-honors-and-awards","11":"category-news","12":"category-research-academics","13":"tag-ben-stein","14":"tag-national-institutes-of-health","15":"tag-zayda-dominick","16":"entry"},"yoast_head":"\nIf at first you succeed: UTC chemistry professor lands research grant on initial attempt | UTC News Archive: Jul 2007 - 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