{"id":51649,"date":"2023-09-20T07:42:44","date_gmt":"2023-09-20T11:42:44","guid":{"rendered":"https:\/\/blogarchive.utc.edu\/news\/?p=51649"},"modified":"2023-09-22T07:36:31","modified_gmt":"2023-09-22T11:36:31","slug":"less-painful-less-scary-utc-researchers-looking-for-better-way-to-screen-for-cancer","status":"publish","type":"post","link":"https:\/\/blogarchive.utc.edu\/news\/2023\/09\/less-painful-less-scary-utc-researchers-looking-for-better-way-to-screen-for-cancer\/","title":{"rendered":"Less painful, less scary: UTC researchers looking for better way to screen for cancer"},"content":{"rendered":"
\"Baker

Baker Garrison, who plans to graduate from UTC in May 2024 with a bachelor\u2019s degree in chemistry, conducts blood sample research. Garrison is part of a faculty and student team testing whether blood samples can be used to screen for endometrial cancer. Photo by Angela Foster.<\/p><\/div>\n

Screening for endometrial cancer, a type of cancer that begins in the uterine wall, can be an invasive, uncomfortable and frightening experience for many women.<\/p>\n

Two professors and their colleagues at the University of Tennessee at Chattanooga are trying to make the procedure much simpler and less scary.<\/p>\n

UC Foundation Professor Steven Symes in the Department of Chemistry and Physics and UC Foundation Professor Sean Richards in the Department of Biology, Geology and Environmental Science are testing whether blood samples can be used to screen for endometrial cancer.<\/p>\n

Baker Garrison, who plans to graduate from UTC in May 2024 with a bachelor\u2019s degree in chemistry, is a research team member. Dr. Kris Amrhein, who graduated in 2017 from UTC with bachelor\u2019s degrees in biochemistry and biology, also is a team member; he earned a master\u2019s and Ph.D. in analytical chemistry from the University of Memphis.<\/p>\n

Detecting endometrial cancer requires an invasive biopsy in which a small tube is inserted through the cervix into the uterus and a tissue sample is taken from the uterine lining. The sample is then examined under a microscope.<\/p>\n

The new test only would require blood being drawn and run through a spectrometer. Computer software will then indicate whether there are blood-borne indicators of possible cancer. If so, further tests will be recommended.<\/p>\n

Symes stresses that the experimental endometrial cancer test does not provide a positive indication of the disease.<\/p>\n

\u201cWe\u2019re not diagnosing cancer,\u201d Symes said. \u201cIf you\u2019re positive on our screening test, that means much more significant follow-up is needed.\u201d<\/p>\n

\u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2014<\/p>\n

Click here to learn about the UTC Department of Chemistry and Physics<\/strong><\/a><\/p>\n

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When it hasn\u2019t spread outside the uterus, endometrial cancer\u2019s five-year survival rate is 96%, according to the American Cancer Society.<\/p>\n

For the research, blood comes from patients at Erlanger Hospital. The samples include patients who have cancer and those who don\u2019t, Symes said. Samples aren\u2019t labeled, he said, so there is no indication whether it\u2019s healthy or unhealthy blood.<\/p>\n

The screening process has been shown to be accurate through research conducted by Dr. Jacopo Troisi, a professor in the Department of Chemistry and Biology at the University of Salerno in Italy and CEO of Theoreo Srl, a research company. But those results must be duplicated elsewhere to validate their findings, Symes said.<\/p>\n

At UTC, no actual blood samples have been used at this point. The focus right now is on calibrating the equipment used to run the tests. It\u2019s different than what was used in the Italian research, Symes said, so getting the same results from different equipment will solidify the validity of the technological process and the results\u2014a necessary step in the overall research.<\/p>\n

Once confirmed as accurate, test results from blood samples can be used to determine whether other factors\u2014such as eating habits, genetics and environmental conditions\u2014may influence the presence of cancer.<\/p>\n

\u201cIf there\u2019s really something there, and it\u2019s really due to just human biochemistry, there may be factors that change things a little bit,\u201d Symes said.<\/p>\n

Over the years, through his collaborations with Erlanger doctors in his toxicology research, Richards has collected some of the blood samples used in the research. He also developed the questionnaires that patient volunteers are asked to fill out.<\/p>\n

\u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2014<\/p>\n

Click here to learn about the UTC Department of Biology, Geology and Environmental Science<\/strong><\/a><\/p>\n

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Once substances indicate the possible presence of cancer, Richards said he wants to trace backward to see if there are any reasons why these patterns crop up.<\/p>\n

\u201cWe can then go back and say, \u2018OK, this pathway is associated with exposure to this metal or this pesticide,\u2019 and then we start looking back on the woman\u2019s history,\u201d Richards said. \u201cWe need to know what their lifestyle\u2019s like. Do they smoke? How many children they\u2019ve had and so forth.\u201d<\/p>\n

Ultimately, tests similar to the ones used for endometrial cancer may be developed to screen for many types of cancers, Richards said.<\/p>\n

\u201cWe could screen them once a year, twice a year, three times a year through blood or saliva or urine, something very easy to collect and say, \u2018You\u2019re showing biological markers that cancer is developing,\u2019 and this is without going in and taking tissue samples,\u201d he said.<\/p>\n

\u201cIf it\u2019s something very simple, then we can increase the screening rate and we can get more women in there.\u201d<\/p>\n

Learn More<\/h4>\n

Visit UTC<\/a><\/p>\n

Department of Chemistry and Physics<\/a><\/p>\n

Department of Biology, Geology and Environmental Science<\/a><\/p>\n

How to Apply<\/a><\/p>\n

\"Endometrial <\/a> <\/div>
\"Endometrial <\/a> <\/div> <\/div>
\"Endometrial <\/a> <\/div> <\/div> <\/div> <\/div>\n","protected":false},"excerpt":{"rendered":"

A team led by UC Foundation Professor Steven Symes in the Department of Chemistry and Physics and UC Foundation Professor Sean Richards in the Department of Biology, Geology and Environmental Science is testing whether blood samples can be used to screen for endometrial cancer.<\/p>\n

Continue Reading <\/a><\/span><\/p>\n","protected":false},"author":1105,"featured_media":51651,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","_ef_editorial_meta_date_first-draft-date":"","_ef_editorial_meta_paragraph_assignment":"","_ef_editorial_meta_checkbox_needs-photo":"","_ef_editorial_meta_number_word-count":"","_ef_editorial_meta_checkbox_slider":"","_ef_editorial_meta_checkbox_featurette":"","_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[48128,70,123864,123865,61,3,122313,7712,48007,661],"tags":[122901,7222,122899,7296,122902,122900],"class_list":{"0":"post-51649","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-academics","8":"category-advancement-and-alumni","9":"category-biology-geology-and-environmental-science","10":"category-chemistry-physics","11":"category-college-of-arts-sciences","12":"category-community","13":"category-experiential-learning","14":"category-faculty-and-staff","15":"category-research-academics","16":"category-students","17":"tag-baker-garrison","18":"tag-dr-steven-symes","19":"tag-endometrial-cancer","20":"tag-erlanger-hospital","21":"tag-kris-amrhein","22":"tag-sean-richards","23":"entry"},"yoast_head":"\nLess painful, less scary: UTC researchers looking for better way to screen for cancer | UTC News Archive: Jul 2007 - 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